As individuals age, they inevitably experience a decline in muscle strength. But what is the underlying mechanism behind this decline? Scientists have now uncovered the answer.
Experts from the Wellcome Sanger Institute in the UK and Sun Yat-sen University in China have created a map of the human body identifying a specific area that plays a role in the nerve degeneration associated with aging.
The aim of this research is to develop a comprehensive map of all human cells to advance the understanding of physical health, disease diagnosis and treatment.
During this process, researchers also investigated why muscles weaken with age.
For this purpose, they analyzed samples from 17 individuals aged 20 to 75 years.
The study identified genes that control ribosomes crucial for protein synthesis in the body. It was found that the mobility of ribosomes in the cells of older individuals decreased.
As a result with aging, our bodies lose the ability to regenerate muscles efficiently.
Furthermore, the study revealed the production of certain molecules called CCN2 molecules responsible for causing inflammation in muscles and accelerating muscle degeneration.
According to researchers, this discovery opens avenues for developing new treatments to improve muscle health and quality of life in the elderly.
They emphasized the importance of further research in this area to develop novel therapies for maintaining muscle health with aging.
The findings of this study were published in the journal Nature Aging.
