Rosie O’Donnell says Mounjaro helped her feel better at 64

Rosie O'Donnell says she has never felt healthier than she does now, crediting the weight-loss drug Mounjaro for the change.

Rosie O’Donnell says she has never felt healthier than she does now, crediting the weight-loss drug Mounjaro for the change. The comedian opened up about her health journey during a recent podcast appearance.

Speaking with Amy Poehler on the “Good Hang” podcast on Tuesday, O’Donnell shared how much more comfortable she feels in her body today. She admitted it’s bittersweet that it took until age 64 to reach this point.

O’Donnell explained that Mounjaro played a significant role in that shift. She revealed she started taking the drug three years ago after her doctor prescribed it specifically to manage her diabetes.

She was clear that weight loss was never the original goal or focus. According to O’Donnell, her doctor was solely concerned with improving her blood sugar numbers at the time.

She recalled first noticing changes in her appetite around the time of her son’s engagement dinner. At that event, she found herself completely unable to eat.

Initially, O’Donnell assumed the loss of appetite was tied to emotional grief. She was missing her late mother deeply during that period and thought sadness was affecting her eating.

But when she eventually stepped on the scale, the results alarmed her enough to call her doctor immediately. She feared something serious might be wrong with her health.

O’Donnell recalled breaking down in tears during that call, worried she might have cancer. She explained that she had lost 12 pounds without making any conscious changes to her routine.

She said the sudden, unexplained weight loss was unlike anything she had experienced before. That moment marked a turning point in understanding how the medication was affecting her body.

Mounjaro is commonly prescribed for both type 2 diabetes and long-term weight management. The drug received FDA approval back in 2022 and has since become widely discussed among public figures.

O’Donnell’s candid reflection adds to a growing number of celebrities openly discussing their experiences with prescription weight-loss medications. Her comments offer a personal look at how a treatment meant for one condition ended up reshaping another part of her life entirely.